Which combination of features is typical of Cushing syndrome due to chronic corticosteroid use?

Which combination of features is typical of Cushing syndrome due to chronic corticosteroid use?

• A. Edema and Fluid Retention
• B. Moon Face, Trunk Obesity, Slender Extremities
• C. Hypertension With Bradycardia and Edema
• D. Weight Loss With Fatigue

Answer: (B)

Chronic corticosteroid use causes Cushingoid changes from cortisol-like effects, including redistribution of fat and muscle wasting. The most distinctive presentation is a rounded, puffy face (moon facies) with fat accumulating around the trunk (central obesity) and thinning of the limbs due to proximal muscle loss. This combination—moon face, trunk obesity, and slender extremities—perfectly captures the typical exogenous Cushingoid appearance. Hypertension can occur, but bradycardia is not typical, and weight loss with fatigue is not characteristic of cortisol excess. Edema may be present, but the key feature is the facial rounding with central obesity and limb thinning.

Chronic corticosteroid use causes Cushingoid changes from cortisol-like effects, including redistribution of fat and muscle wasting. The most distinctive presentation is a rounded, puffy face (moon facies) with fat accumulating around the trunk (central obesity) and thinning of the limbs due to proximal muscle loss. This combination—moon face, trunk obesity, and slender extremities—perfectly captures the typical exogenous Cushingoid appearance. Hypertension can occur, but bradycardia is not typical, and weight loss with fatigue is not characteristic of cortisol excess. Edema may be present, but the key feature is the facial rounding with central obesity and limb thinning.