Which statement best describes the relationship between long-term corticosteroid use and Cushing syndrome?

Which statement best describes the relationship between long-term corticosteroid use and Cushing syndrome?

• A. Abruptly Stopping Steroids
• B. Lack of ACTH
• C. Poorly Functioning Adrenal Glands
• D. Taking Corticosteroids for Many Years

Answer: (D)

Long-term corticosteroid use causes Cushing syndrome by delivering excess glucocorticoids into the body. When steroids are taken for many years, their glucocorticoid activity mirrors high cortisol levels, producing the hypercortisolism that defines Cushing syndrome. The body’s negative feedback reduces ACTH, and the adrenal glands may atrophy, so endogenous cortisol production drops. Stopping steroids abruptly after prolonged use can lead to adrenal insufficiency rather than a recurrence of Cushing syndrome. The other statements describe withdrawal effects or adrenal underactivity, not the result of sustained external steroid exposure.

Long-term corticosteroid use causes Cushing syndrome by delivering excess glucocorticoids into the body. When steroids are taken for many years, their glucocorticoid activity mirrors high cortisol levels, producing the hypercortisolism that defines Cushing syndrome. The body’s negative feedback reduces ACTH, and the adrenal glands may atrophy, so endogenous cortisol production drops. Stopping steroids abruptly after prolonged use can lead to adrenal insufficiency rather than a recurrence of Cushing syndrome. The other statements describe withdrawal effects or adrenal underactivity, not the result of sustained external steroid exposure.